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Image Search Results
Journal: bioRxiv
Article Title: Coarse Raman and optical diffraction tomographic imaging enable label-free phenotyping of isogenic breast cancer cells of varying metastatic potential
doi: 10.1101/2020.09.23.309138
Figure Lengend Snippet: (A) Representative coarse Raman maps reconstructed using the 1452 cm -1 peak intensity shown for P231, CTC, and LM cells. (B) Mean Raman spectra (with the shadow representing 1 s.d. and vertical offset for clarity) are shown and some prominent biological peaks highlighted for the three isogenic cell lines used in the study. (C) The three MCR component loadings derived from the combined spectral dataset are shown. MC1, MC2, and MC3 respectively show cytoplasm-like, nucleus-like, and quartz background spectral features. (D) The segmentation maps constructed by thresholding on MCR component scores for the cells in panel A are shown. The violin plots with embedded box and whisker plots show the distribution of MCR scores for cytoplasm-like (E) and nucleus-like (F) loadings. The scale bars represent 2 μm. * represents statistically significant differences at p < 0.05 threshold (Wilcoxon rank-sum test).
Article Snippet: All the
Techniques: Derivative Assay, Construct, Whisker Assay